Endocrinology and Diabetes (Specialty Certificate Examination): SEND Exam
"Endocrinology and Diabetes (Specialty Certificate Examination)", also known as SEND exam, is a MRCPUK Certification. With the complete collection of questions and answers, PrepPDF has assembled to take you through 200 Q&As to your SEND Exam preparation. In the SEND exam resources, you will cover every field and category in MRCPUK Certification Certification helping to ready you for your successful MRCPUK Certification.
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- Exam Code: SEND
- Exam Name: Endocrinology and Diabetes (Specialty Certificate Examination)
- Certification Provider: MRCPUK
- Corresponding Certification: MRCPUK Certification
- Updated: Jul 18, 2026
- No. of Questions: 200 Questions & Answers with Testing Engine
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MRCPUK SEND Exam Syllabus Topics:
| Section | Weight | Objectives |
|---|---|---|
| Topic 1: Diabetes Mellitus | 40% | - Other forms of diabetes
|
| Topic 2: Reproductive and Other Endocrine Conditions | 15% | - Disorders of puberty and sex development - Obesity and lipid disorders - Polycystic ovary syndrome - Endocrine hypertension and rare syndromes |
| Topic 3: Thyroid Disorders | 15% | - Hyperthyroidism: Graves’ disease, toxic nodular disease - Hypothyroidism and myxoedema coma - Thyroid nodules and cancer - Thyroiditis and subclinical dysfunction |
| Topic 4: Adrenal and Parathyroid/Metabolic Bone Disorders | 15% | - Hyperparathyroidism, hypoparathyroidism - Osteoporosis, osteomalacia, Paget's disease - Cushing's syndrome, Addison's disease, phaeochromocytoma - Primary/secondary hyperaldosteronism |
| Topic 5: Pituitary and Hypothalamic Disorders | 15% | - Diabetes insipidus and SIADH - Hypopituitarism and hormone replacement - Pituitary adenomas: prolactinoma, acromegaly, Cushing's disease - Hypothalamic dysfunction |
MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) Sample Questions:
1. A 54-year-old woman attended clinic for routine follow-up. She had Cushing's syndrome secondary to ectopic adrenocorticotropic hormone syndrome with no primary source identified.
She had declined bilateral adrenalectomy. Routine medication included metyrapone 500 mg three times daily, ketoconazole 200 mg once daily and hydrocortisone 10 mg in the morning and 5 mg in the evening.
Metyrapone inhibits the action of which enzyme in steroidogenesis?
A) 5?-reductase
B) 11?-hydroxylase
C) 3?-hydroxysteroid dehydrogenase
D) 21-hydroxylase
E) 17?-hydroxylase
2. A 26-year-old woman presented with recurrent Graves' disease. After discussing the treatment options, she chose radioiodine.
What dose of radioiodine is most appropriate in uncomplicated Graves' disease?
A) 100-200 MBq
B) 400-600 MBq
C) 700-900 MBq
D) 1400-1600 MBq
E) 1000-1200 MBq
3. A 28-year-old Asian woman was seen in the joint diabetes-antenatal clinic at 16 weeks' gestation. She gave a history of gestational diabetes during her previous pregnancy. She had a strong family history of diabetes mellitus. She was fit and well, and had no symptoms other than slight early morning sickness.
According to NICE guidance (NG3, February 2015) for management of pregnancy, what is the most appropriate way to screen for gestational diabetes in this woman?
A) oral glucose tolerance test at 24-28 weeks' gestation
B) oral glucose tolerance test as soon as possible
C) haemoglobin A1c
D) fasting plasma glucose
E) 2-h postprandial plasma glucose
4. A 55-year-old man with mild polyuria and tiredness was seen on a renal ward. He had had a living-related kidney transplant 6 months previously. He had good graft function while being treated with prednisolone 5 mg daily, mycophenolate mofetil 1 g twice daily and tacrolimus 3 mg twice daily. He was also taking atenolol 50 mg daily and simvastatin 40 mg daily.
Investigations:
haemoglobin A1c75 mmol/mol (20-42)
random plasma glucose18.0 mmol/L
Which drug is most likely to be responsible for his diabetes of new onset?
A) prednisolone
B) mycophenolate mofetil
C) tacrolimus
D) simvastatin
E) atenolol
5. A 55-year-old dental nurse was referred for bone densitometry after sustaining a non-displaced fracture of the femur after falling down a step. She had experienced no other fractures. Her only medical problem was long-standing anaemia of unknown cause. The only family history was of persistent dental abscesses affecting her father. She had three children who were well. She was taking no medication.
Examination was normal.
Investigations:
haemoglobin102 g/L (115-165)
MCV85 fL (80-96)
white cell count6.0 ? 109/L (4.0-11.0)
platelet count245 ? 109/L (150-400)
erythrocyte sedimentation rate25 mm/1st h (<30)
serum creatinine85 umol/L (60-110)
serum corrected calcium2.40 mmol/L (2.20-2.60)
serum alkaline phosphatase56 U/L (45-105)
DXA scan spine (L2-L4)T score +5.8
DXA scan total hipT score +5.4
What is the most likely diagnosis?
A) Paget's disease
B) osteopetrosis
C) high bone mass phenotype
D) myelodysplasia
E) fluorosis
Solutions:
| Question # 1 Answer: B | Question # 2 Answer: B | Question # 3 Answer: B | Question # 4 Answer: C | Question # 5 Answer: B |
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